Glucocorticoid Receptor Novocastra
The glucocorticoid receptor of molecular weight 90 kD has three main functional regions; the N-terminal modulating region, the DNA binding region and the C-terminal steroid binding region. The glucocorticoid receptor is reported to be widely distributed and expressed in many cultured cell lines eg CEM-C7. Glucocorticoid receptor is reported to be expressed in neoplastic cells of chronic lymphocytic leukemia (CLL). Two isoforms of glucocorticoid receptor exist; alpha and beta, with the alpha form usually the most abundant. The control of gene expression by glucocorticoids has been widely studied as a model for transcriptional regulation.Glucocorticoid receptors are reported to induce or repress the expression of genes in response to glucocorticoids, mediating such processes as cell growth, differentiation and apoptosis. Glucocorticoid receptors may also form a complex with heat shock protein 90 and in certain instances render the non-ligand bound receptor transcriptionally inactive.
Product Specific Information
NCL-GCR is raised to the N-terminal modulating region.
|GCR||1ml NCL-GCR||Lyophilised Concentrated Monoclonal Antibody||P(HIER), W||Info||MSDS||1|
|GCR-U||1ml NCL-GCR US IVD||Lyophilised Concentrated Monoclonal Antibody||P(HIER), W||Info||MSDS||1|