43 result(s) for 'Prostate'
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Prostate Biopsy Kits are a convenient means for the proper collection, identification and transportation of prostate biopsies. Kits
contain either 8, 12, or 16 prefilled 10% neutral buffered formalin containers arranged in prelabeled positions that correlate with the area of the prostate from which the sample was taken.
Antigen Background
Prostate specific antigen (PSA) is a 34 kD protein belonging to the kallikrein family of serine proteases and was originally isolated and purified from human seminal plasma. It was found to be immunologically identical and biologically similar to a protein isolated from the prostate gland. PSA is distinct from prostatic acid phosphatase. Low levels of expression of PSA have been reported in non-prostatic tissues and tumors such...
Analyte Specific Reagent. Analytical and performance characteristics are not established.
The transmembrane protease serine 2 gene (TMPRSS2) is involved in gene fusions with ERG, ETV1 or ETV4 in prostate cancer. It has been reported that the expression of the TMPRSS2-ERG fusion gene is a strong prognostic factor for the risk of prostate cancer recurrence in prostate cancer patients treated by surgery. The TMPRSS2-ERG rearrangement probe is optimized to detect the deletion between TMPRSS2 and ERG at 21q22 associated with the TMPRSS2-ER...
The androgen receptor (AR) gene has been identified as a target gene for the Xq12 amplification found in one-third of hormone-refractory prostate cancers. The findings suggest that AR gene amplification and overexpression is involved in the emergence of prostate cancer. The AR (Xq12) FISH probe is optimized to detect copy numbers of the AR gene region at region Xq12. The chromosome X satellite enumeration probe (SE X) at DXZ1 is included to facil...
Antigen Background
E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In p...
Antigen Background
The expression of different cytokeratins in epithelial-derived tumors and the general tendency towards maintenance of cytokeratin polypeptide patterns during malignant growth and metastasis serves as a basis for approaching the characterization of tumors, using cytokeratins as differentiation markers.
Origin Cytokeratin (Clone 34?E12) is recommended for the characterization of squamous and ductal carcinomas arising from complex...