BCL6 (3q27) Break - XL for BOND FISH probe detects genomic translocations involving the BCL6 gene. BCL6 (3q27) Proximal - XL and BCL6 (3q27) Distal - XL probes are optimized to detect the genomic regions proximal and distal to break points in the BCL6 gene region.When combined, both probes are used to detect translocations involving the BCL6 gene at 3q27.

Chromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. Kreatech has developed this probe for the specific use on cell material (KBI-10607), or on tissue (KBI-10730). Two different breakpoint regions have been identified; the major breakpoint region (MBR) is located within the 5' noncoding region of the BCL6 proto-oncogene, while the ...

Chromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. Kreatech has developed this probe for the specific use on cell material (KBI-10607), or on tissue (KBI-10730). Two different breakpoint regions have been identified; the major breakpoint region (MBR) is located within the 5' noncoding region of the BCL6 proto-oncogene, while the ...

Antigen Background Bcl-6は、95 kD のクルッペル型ジンクフィンガータンパクをコードする癌原遺伝子で、他の転写因子と相同性を示します。Bcl-6タンパクは主に正常胚中心B細胞とB細胞性リンパ腫に発現します。Bcl-6 癌原遺伝子は非ホジキンリンパ腫における3q27での染色体再構成に関与していることが明らかになっており、Bcl-6再構成は、びまん性大細胞型B細胞性リンパ腫の33-45%に検出されています。濾胞性リンパ腫、びまん性大細胞型B細胞性リンパ腫、バーキットリンパ腫および結節性リンパ球優位型ホジキン病では、Bcl-6遺伝子産物が免疫組織化学的に検出されることが報告されています。 Product Specific Information Clone LN22抗体は、内因性ペルオキシダーゼ処理（過酸化水素処理）を一次抗体の前にすると染色性が減弱する可能性があるため、一次抗体の後に行ってください。 Disclaimer Bcl-6 Oncoprotein is r...

Antigen Background The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from...

Slide 1 Hello, hello; thank you so much for that introduction. Let's get started. Oh, I'm sorry, I just need to hit this next button here. So my name is Mark Lawson. Thank you for joining us in this webinar. I'm here to present BOND RX tips, tricks, and optimization. It's going to be a user guide from the BOND RX and chromogenic multiplexing in the research application. Slide 2 So, my name is Mark Lawson. I'm an application specialist on the Life Sciences team at Leica Biosystems I provide technical support for the Life Sciences portfolio, including but not limited to the BOND RX, the BOND RXm, and a wide array of reagents. So I've worked in the histology field for about 15 years and in both clinical and research spaces. I started off as a histotechnologist and worked my way up...

Biomarkers AE1/AE3 (1) AMACR (2) BCL6 (1) CD163 (2) CD20 (2) CD3 (9) CD4 (5) CD68 (5) CD8 (10) CDX2 (2) CK20 (5) Ck5 (4) ...