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Drug development is a timely and costly process, with the average cost of bringing a single new drug to market costing $1.3 billion, taking anywhere between 10-15 years to finalize complete all clinical trials. Preclinical studies are the vital first steps in research and development and is estimated to cost $7M over 73 months. Up to 35% of drugs are eliminated at phase I and II clinical trials due to toxicity.

Following our 2-part webinar series of Tips & Tricks to Better Histology, questions about histology-related issues were received from customers and answered by Leica Biosystems. Here, in Histology Tips & Tricks: Questions and Answers, Part 2, more questions are answered, specifically regarding decalcifying agents, and tissue section bubbling/cracking.

Immunohistochemistry (IHC) detects proteins of interest within whole tissue sections, keeping cellular organization intact.

Leica biosystems BOND RX stainer can aid biomarker and drug discovery by offering fast, customized, consistent, fluorescent or chromogenic multiplex IHC and ISH on your research samples. The result? Freeing up your time to innovate, investigate and discover!

The first virtual event of the year recaptured the conference atmosphere at the Multiplex User Meeting. With Leica Biosystems total multiplex solutions and trusted partners, advances in multiplex IHC were innovatively showcased to customers via live presentations, on-demand webinars, virtual exhibition hall, networking room and, virtual lab tour!

Digital pathology is the means of capturing stained slides as high-resolution, brightfield or fluorescent images that are managed, stored, and visualized digitally. Digital pathology has several advantages over traditional microscopy that can improve project productivity and quality. This infographic highlights key benefits of implementing digital pathology in the laboratory. 

  • Helen Snyder ,
    PhD, Director of Preclinical Development and Strategic Partnerships Cell IDx

At the Multiplex User Meeting hosted via LabRoots, Helen Snyder, PhD delivered a live session detailing Cell IDx’s UltraPlex chromogenic multiplex IHC technology. Their chromogenic detection system of 3-4 markers simultaneously is developed to run on BOND RX autostainer in 4-5 hours,  providing maximal information on small tissue samples for biomarker discovery. 

There is an ever-increasing demand to derive more information from limited research samples. Establishing expression profiles of the tumor microenvironment can be achieved via multiplex staining now with chromogenic detection. Discover how the new features of the Leica Biosystems BOND research system and new assays combine to support automated 6-plex chromogenic multiplexing.

Following our two-part webinar series of Tips & Tricks to Better Histology, further questions were raised by customers referring to specific issues encountered during histology/staining practice. Some of these questions are answered here to help combat issues experienced in the laboratory. 

In Part 1 of a two-part webinar series hosted originally on LabRoots, Fiona Tarbet gives a comprehensive overview focusing on how to mitigate the common issues experienced during histology that subsequently affect the stages of tissue preparation and processing.