Wilms' Tumor
Primary Antibodies
Wilms' Tumor

Human Wilms tumor: immunohistochemical staining for WT1 using NCL-L-WT1-562. Note intense nuclear staining of malignant cells. Paraffin section.
Antigen Background
Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.

CLONE: WT49
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Code | Name | Configuration | Use | Datasheet | MSDS | Qty |
---|---|---|---|---|---|---|
PA0562 | 7ml Wilms Tumor Bond RTU Prim |