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Human Herpesvirus Type 8 (HHV8) Primary Antibodies

Human Herpesvirus Type 8 (HHV8)

Human skin, Karposi sarcoma: immunohistochemical staining of HHV8. Note nuclear staining of neoplastic spindle cells. Human Herpes Virus 8; clone 13B10.
Human skin, Karposi sarcoma: immunohistochemical staining of HHV8. Note nuclear staining of neoplastic spindle cells. Human Herpes Virus 8; clone 13B10.

Antigen Background

Human herpesvirus type 8 (HHV8), is the proposed etiological agent of Kaposi's sarcoma (KS). It is reported that HHV8 has been demonstrated in KS tissues by immunohistochemistry, in situ PCR and also in situ hybridization. HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncogenic activity. HHV8 has been reported to be expressed in multicentric Castleman's disease (MCD) and in angioimmunoblastic lymphadenopathies. The localization of HHV8 in subcapsular spindle cell proliferations, which is where early intranodal KS begins, and endothelial cells in Castleman's disease may explain the link between intranodal KS and MCD. In MCD, HHV8 is reported to be expressed in mantle zone large immunoblastic B cells.

Product Notification

PA0050 is for use with BDD v 75 for BOND Software version 5.1 and higher. Please contact your local Leica Biosystems Representative with any questions.


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CLONE: 13B10

Material with code "HHV8 PROBE" is discontinued , possible alternatives:
Material with code "HHV8 (LNA)" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
PA0050 7ml Herpesvirus(Type 8) (13B10) Bond RTU Bond ready to use reagent P(HIER) Info MSDS
HHV8-LNA-L-CE 1ml NCL-L-HHV8-LNA Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
HHV8-LNA-CE-S 0.1ml NCL-HHV8-LNA Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
HHV8-LNA 1ml NCL-HHV8-LNA Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS
HHV8-LNA-S 0.1ml NCL-HHV8-LNA Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS
HHV8-LNA-CE 1ml NCL-HHV8-LNA Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
Material with code "HHV8 PROBE" is discontinued , possible alternatives:
Material with code "HHV8 (LNA)" is discontinued , possible alternatives:

Request a quote

Code Name Configuration Use Datasheet MSDS Qty
HHV8 1ml NCL-HHV8 Liquid Probe P Info MSDS