The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton.Beta-catenin's role is as a transcription effector of the wnt-signalling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.
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|PA0083||7ml Beta-Catenin Bond RTU Primary|