P120 catenin is a regulator of cell-cell adhesion, achieved through interaction with classical and Type II cadherins. Evidence also exists for a role in the regulation of cadherin availability on the cell surface. P120 catenin also regulates actin dynamics, placing it as a potential master regulator of the cell motility/cell adhesion phenotypes.
Recent studies have suggested a tumour-suppression role for p120, with loss of p120 expression implicated in the development of a tumour microenvironment and induction of metastatic progression. The expression of p120 Catenin has been highlighted in early lobular breast neoplasias.
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|PA0379||7ml p120 Catenin (EP66) Bond RTU Primary|