53 result(s) for 'Histopathology'
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This Item has been discontinued
Replaced by Leica CM1860
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This Item has been discontinued
Replaced by Leica CM1860 UV
H&E is an important tool for disease research and drug development and is being increasingly combined with digital pathology technology. Image quality is important for slide digitization to ensure that interpretation is accurate. Take a look at some images here, produced by our digital pathology scanners.
In the webinar Cryosectioning 101 for Research, John Stock provided a comprehensive guide on achieving better cryosectioning outcomes. John went on to answer customer questions at the end of the session, that have been compiled for your viewing here.
Antigen BackgroundProgrammed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of progn...
Antigen Background
Mammaglobin is a 10 kDa glycoprotein that belongs to the uteroglobin family of proteins. It was first described in 1996 and found to be overexpressed in breast cancer. Mammaglobin has been suggested as a useful marker for carcinomas of unknown primary origin, with expression unaltered from the primary site.
Disclaimer
Mammaglobin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues...
Antigen Background
This monoclonal antibody recognizes both wild type and mutant forms of human p53 protein under denaturing and non-denaturing conditions. The epitope recognized by clone DO-7 can be destroyed by prolonged fixation in buffered formalin. The heat induced epitope retrieval technique may improve staining in some cases.
Disclaimer
p53 Protein is recommended for the detection of specific antigens of interest in normal and neoplastic t...
Antigen Background
Cytoplasmic actins are part of the microfilament system of cytoskeletal proteins. Smooth muscle actin is found in vascular walls, intestinal muscularis mucosae and muscularis propria and in the stroma of various tissues.
Product Specific Information
Enzyme pretreatment may enhance staining in some cases.
Disclaimer
SMA (Alpha Smooth Muscle Actin) is recommended for the detection of specific antigens of interest in normal and ne...
Antigen Background
The c-kit proto-oncogene encodes a transmembrane receptor with tyrosine kinase activity, c-kit (CD117), which is closely-related to the platelet-derived growth factor receptor family. c-kit plays a role during hematopoiesis, gametogenesis and melanogenesis. The expression of CD117 antigen is of particular interest in the study of gastrointestinal stromal tumors (GIST), small lung cell carcinomas and in melanomas.
Disclaimer
CD1...