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Peer-Reviewed Publications Repository - Aperio VERSA

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Long-term Exposure To House Dust Mites Accelerates Lung Cancer Development In Mice

Publication Year: 2023
Country: USA
PMID: N/A
Publication: J Exp Clin Cancer Res (2023) 42:26 https://doi.org/10.1186/s13046-022-02587-9
Institute: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA.
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The State Key Laboratory of Respiratory Disease, Guang- dong Provincial Key Laboratory of Allergy and Clinical Immunology, Center for Immunology, Inflammation and Immune-Mediated Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Networked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Hospital General Universitario de Alicante, Alicante, Spain.
Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.
Cell IDx Inc, San Diego, CA, USA.
Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children’s Hospital of San Diego, University of California San Diego, La Jolla, CA, USA.
Tissue Technology Shared Resource, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Division of Endocrinology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Medical Research Service, Veteran Affairs San Diego Healthcare System, San Diego, CA, USA.

Instrument:

Aperio VERSA
Authors: Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Grifn, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M. González Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hofman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz and Samuel Bertin
Study Goals: Individuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic exposure to house dust mites (HDM), a common indoor aeroallergen associated with the development of asthma, accelerates LC development through the induction of chronic lung inflammation (CLI).
Keywords: Lung cancer, Kras, Urethane, House dust mites, Chronic inflammation, NLRP3, IL-1β, CCL2, Macrophages, Tumor microenvironment
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Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer.

Publication Year: 2022
Country: USA
PMID: 35831288
Publication: Nat Commun. 2022;13(1):4053. Published 2022 Jul 13. doi:10.1038/s41467-022-31769-4
Institute: Tempus Labs, Inc., Chicago, IL 60654 USA
Department of Pathology, University of Chicago, Chicago, IL 60637 USA

Instrument:

Aperio VERSA
Authors: Lau D, Khare S, Stein MM, et al.
Study Goals: To investigate whether cytotoxic CD4+ T cells mediate anti-tumor activity via HLA-II on tumor cells and augment HLA-I-dependent cytotoxic CD8+ T cell interactions to drive ICB response in NSCLC.
Keywords: Tumour biomarkers, Non-small-cell lung cancer, Data integration, Tumour immunology, Translational research
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UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry.

Publication Year: 2022
Country: USA
PMID: 34331291
Publication: Methods Mol Biol. 2021;2350:267-287. doi:10.1007/978-1-0716-1593-5_17
Institute:

Cell IDx, San Diego, CA, USA.
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA.
Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, USA.

Instrument:

Aperio VERSA
Authors: Levin M, Flor AC, Snyder H, Kron SJ, Schwartz D.
Study Goals: To describe the UltraPlex method for multiplexed two-dimensional fluorescent immunohistochemistry
Keywords: Antibody; Hapten; Immunofluorescence; Immunohistochemistry; Microscopy; Multiplex imaging.
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Deep Learning of Histopathology Images at the Single Cell Level.

Publication Year: 2021
Country: USA
PMID: PMC8461055
Publication: Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641
Institute: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Instrument:

Aperio VERSA
Authors: Lee K, Lockhart JH, Xie M, et al.
Study Goals: To systematically  review the various machine learning methods with a focus on cell-level analysis.
Keywords: Aperio VERSA, histopathology image analysis, deep learning, image data labeling, cell type classification, tumor immune microenvironment, tumor heterogeneity
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NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice.

Publication Year: 2021
Country: China
PMID: PMC8535822
Publication: Science Advances. 2021;7(43). doi:10.1126/sciadv.abi9471
Institute: State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital of Xiamen University, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102,

Instrument:

Aperio VERSA
Authors: Zhang P, Liu Y, Hu L, et al.
Study Goals: To study NLRC4-mediated cell death and tissue damage
Keywords: Aperio VERSA
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In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.

Publication Year: 2021
Country: USA
PMID: PMC8554823
Publication: ACS Central Science. 2021;7(10):1638-1649. doi:10.1021/acscentsci.1c00529
Institute: Department of Radiology and Biomedical Imaging

Instrument:

Aperio VERSA
Authors: Zhao N, Bardine C, Lourenço AL, et al.
Study Goals: To evaluate whether granzyme biochemistry can be assessed in vivo using an imaging modality that can be scaled vertically into human subjects
Keywords: Aperio VERSA
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Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models.

Publication Year: 2021
Country: USA
PMID: PMC8561005
Publication: iScience. 2021;24(11):103245. doi:10.1016/j.isci.2021.103245
Institute: Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco

Instrument:

Aperio VERSA
Authors: Das M, Mao W, Shao E, et al.
Study Goals: To understand whether Increased expression of TREM2 seems to support microglial activities that counteract AD related network dysfunction
Keywords: Aperio VERSA

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