15 result(s) for 'PDL1'
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Antigen BackgroundProgrammed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of progn...
It’s Time for TIME Alexander “Sandy” Borowsky Professor of Pathology and Laboratory Medicine Center for Immunology and Infectious Diseases
Disclosures Bristol-Meyers Squibb/Celgene: Funded through Investigator Sponsored Research (ISR) program. Discovery proposal. Leica/Aperio: Funded to run the “Genesis” study for primary diagnosis from whole slide images. Honorarium for this presentation. Histolix: Slide-free histology (Levenson and Fereidouni). Pfizer: Pfizer Protocol A9001502, Treatment Resistance Following Therapies (TRANSLATE) site PI. Agenda: In contracting to join the “FLEX” registry. None of these has actually paid me, only funding for the research projects.
Objectives • Introduction into the complexity of the TIME and the development of new cancer treatments though di...
Antigen BackgroundPD-1 (Programmed Death 1) is a 55KDa Type I transmembrane cell surface receptor which is expressed by T-cells during activation. It is also upregulated in B-cells, dendritic cells, natural killer cells and some myeloid cells, suggesting a broad role for PD1 in immune regulation. PD-1 interacts with at least two ligands: PD-L1 and PD-L2. PD-1/PD-L1 interaction is important in many Tcell functions including acute and chronic infla...
Phenotyping Tumor Microenvironment Using DNA Barcoded Multiplex Technology Chifei Sun GSK IVIVTBIBCellular Biomarkers Collegeville, PA
I have no conflict of interests with Leica Biosystems, Ultivue and Indica Labs. – All the materials used in this presentation are for educational purpose only. – The human biological samples were sourced ethically, and their research use was in accord with the terms of the informed consents under an IRB/EC approved protocol. Statement 9/25/2020 2
Understand the complexity of tumor microenvironment and its importance in drug development – Introduce the Ultivue DNA barcoding and exchange technology for multiplex immunofluorescence – Highlight the processes of image fusion, spatial analysis and colocalization of markers on individual cells Learning...
DESCRIPTION: Chromogenic multiplex IHC kit for BOND RX - human PD-L1, CD8, PanCK
SIZE: 10 slides
PRODUCT OVERVIEW: Kit for chromogenic multiplex IHC staining of 10 slides plus a single negative control slide on the BOND RX with V7.0 software.
1° Antibody
Clone
1° Tag
2° Antibody
Chromogen
PD-L1
73-10
UT014
Anti-UT014-HRP
Leica Blue
CD8
EPR10640(2)
UT015
Anti-UT015-AP
Leica Refine Red
PanCK
AE1/AE3
UT016
Anti-UT016-HRP
Yellow
Leica Ref...
DESCRIPTION: Kit for fluorescent multiplex IHC staining of human CD8, CD68, PD-1, PD-L1, detection with 490, 550, 650, 750 nm fluors
SIZE: 5 slides
PRODUCT OVERVIEW: All components required to stain 5 multiplex slides plus a single negative control slide with simple two-step protocol
1° Antibody
Clone
1° Tag
2° Antibody
2° Fluor
CD8
EPR10640(2)
UT015
Anti-UT015
CL490
CD68
C68/684
UT019
Anti-UT019
CL750
PD-1
EPR4877
UT016
Anti-UT016
CL650...
The content of this webinar will encompass detailed technical descriptions of novel and state of the art methods to decalcify tissue samples that will be embedded in paraffin or for frozen sectioning for molecular and nucleic acid analysis for basic research...
DESCRIPTION: Kit for fluorescent multiplex IHC staining of human CD8, CD68, Pan-CK, PD-L1, detection with 490, 550, 650, 750 nm fluors
SIZE: 5 slides
PRODUCT OVERVIEW: All components required to stain 5 multiplex slides plus a single negative control slide with simple two-step protocol.
1° Antibody
Clone
1° Tag
2° Antibody
2° Fluor
CD8
EPR10640(2)
UT015
Anti-UT015
CL490
CD68
C68/684
UT019
Anti-UT019
CL750
Pan-CK
AE1/AE3
UT016
Anti-UT016
...
DESCRIPTION: Kit for fluorescent multiplex IHC staining of human CD68, CD163, Pan-CK, PD-L1, detection with 490, 550, 650, 750 nm fluors
SIZE: 5 slides
PRODUCT OVERVIEW: All components required to stain 5 multiplex slides plus a single negative control slide with simple two-step protocol.
1° Antibody
Clone
1° Tag
2° Antibody
2° Fluor
CD6
C68/684
UT019
Anti-UT019
CL750
CD163
EPR19518
UT015
Anti-UT015
CL490
Pan-CK
AE1/AE3
UT016
Anti-UT016
...
The potential for non-invasive tests that provide equivalent research and diagnostic value as can be obtained from tissue biopsies is real, but not yet realized. Tissue biopsies allow for identification, phenotyping and molecular analysis of cancer and...