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Aperio Microvessel Analysis Algorithm – Detect & Measure Angiogenesis

Aperio Microvessel Analysis Algorithm

Analyzing capillary and microvessel infrastructure is critical in many disease areas. With whole slide scanning and the Aperio Microvessel Analysis Algorithm, a tedious manual counting task can be automated and standardized. Automatically detect and quantify microvessels stained with endothelial markers (e.g. CD31, CD34), generating multiple measurements such as vessel area, perimeter, and density per tissue area.

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Remove subjectivity and variability

Manual review of microvessels is inherently subjective, and subject to inter- and intra-observer variability. With the Aperio Microvessel Analysis Algorithm, data is quantitative, standardized, and reproducible, so you know you are getting consistent results.

Control for sample variance

You have control over the inputs, so you can adjust for tissue preparation and staining variations. Set minimum and maximum staining thresholds, complete partial vessel perimeters, and join up vessel fragments, so you see the true number of vessels in your tissue.

Pick your stain precisely

The Aperio Microvessel Analysis Algorithm uses color deconvolution to detect the chromogen staining microvessels in tissue. The algorithm can help you identify the exact RGB values for your stain, ensuring the deconvolution works accurately on your slides.

Get the details you need

Outputs are detailed and quantitative, giving you a comprehensive dataset on your slides. View different mark-up masks to look at your results in different ways, and output histograms of the data you want, including vessel perimeter, vessel area, lumen area, and total vascular area.

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For Research Use Only. Not for use in diagnostic procedures.

Copyright © 2018 Leica Biosystems Imaging, Inc. All Rights Reserved. LEICA and the Leica logo are registered trademarks of Leica Microsystems IR GmbH. Aperio is a trademark of the Leica Biosystems group of companies in the USA and optionally in other countries.