Oct-3/4 Primary Antibodies

Oct-3/4

Human seminoma: immunohistochemical staining for Oct-3/4 transcription factor using PA0193 (clone N1NK). Note intense staining of pluripotent tumor cells. Paraffin section.
Human seminoma: immunohistochemical staining for Oct-3/4 transcription factor using PA0193 (clone N1NK). Note intense staining of pluripotent tumor cells. Paraffin section.

Antigen Background

Oct3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct3/4 is required to maintain stem cell self replication. Down regulation of Oct3/4 levels are associated with loss of pluripotency. Oct3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary tumor.