Chromogranin A Primary Antibodies

Chromogranin A

Human insulinoma: immunohistochemical staining for chromogranin A using PA0515 (clone 5H7). Note intense cytoplasmic staining of neoplastic islet cells. Paraffin section.
Human insulinoma: immunohistochemical staining for chromogranin A using PA0515 (clone 5H7). Note intense cytoplasmic staining of neoplastic islet cells. Paraffin section.

Antigen Background

Chromogranin A is a 68 kD acidic protein which is reported to be widely expressed in neural tissues and in secretory granules of human endocrine cells eg parathyroid gland, adrenal medulla, anterior pituitary gland, islet cells of the pancreas and C cells of the thyroid. Chromogranin A expression has been reported in neuroendocrine tumors such as pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors and carcinoids.