Mismatch Repair Protein (MLH1) Primary Antibodies

Mismatch Repair Protein (MLH1) Novocastra

Human small intestine: immunohistochemical staining for MLH1 protein using NCL-L-MLH1. Note gradient of staining through the maturing and differentiated epithelial cells of the villi and also in a proportion of the stromal cells. Paraffin section.
Human small intestine: immunohistochemical staining for MLH1 protein using NCL-L-MLH1. Note gradient of staining through the maturing and differentiated epithelial cells of the villi and also in a proportion of the stromal cells. Paraffin section.

Antigen Background

MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in alterations to microsatellite repeats, often referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in some forms of colon cancer, a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.


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代码 名称 Configuration Use Datasheet MSDS 数量
PA0610 7ml MLH1 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS 1
MLH1-L 1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS 1
MLH1-L-CE-S 0.1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS 1
MLH1-L-CE 1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS 1
MLH1-L-S 0.1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS 1