IgA is a member of the antibody class of the immunoglobulin superfamily. There are several classes and subclasses (isotypes) of antibody, the antibody isotype being defined by the immunoglobulin heavy chain present in the molecule. The basic structure of an immunoglobulin molecule consists of two identical heavy chains (γ, µ, α, δ, ε) and two identical light chains, either kappa or lambda. IgA contains the α-chain and may be present in a serum or secretory form. In serum, 90 percent of IgA is monomeric, while in its secretory form it is the main immunoglobulin found in secretions including tears, saliva, intestinal and bronchial mucous, sweat, colostrum, and secretions from the prostate and respiratory epithelia, where it has the job of defending exposed external surfaces of the body against attack from micro organisms. Secretory IgA is synthesized locally by plasma cells and dimerized intracellularly with a cysteine-rich J-chain.
Product Specific Information
Clone N1CLA was developed to produce reduced background staining that is associated with polyclonal antibodies on paraffin sections.
|IGA-L-CE||1ml NCL-L-IgA||Liquid Concentrated Monoclonal Antibody||P(HIER)||Info||MSDS||1|
|IGA-L-S||0.1ml NCL-L-IgA||Liquid Concentrated Monoclonal Antibody||P(HIER), W||Info||MSDS||1|
|IGA-L-CE-S||0.1ml NCL-L-IgA||Liquid Concentrated Monoclonal Antibody||P(HIER)||Info||MSDS||1|
|IGA-L||1ml NCL-L-IgA||Liquid Concentrated Monoclonal Antibody||P(HIER), W||Info||MSDS||1|
|IGAP||1ml NCL-IgAp||Lyophilised Polyclonal||P(ENZYME), W||Info||MSDS||1|
|IGDP-U||1ml NCL-IgDp US IVD||Lyophilised Polyclonal||P(ENZYME)||Info||MSDS||1|
|IGAP-U||1ml NCL-IgAp US IVD||Lyophilised Polyclonal||P(ENZYME), W||Info||MSDS||1|