REPEAT-FREE FISH Technology

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Kreatech FISH Probes are the latest advancement in DNA in situ hybridization. The probes are constructed using the REPEAT-FREE* technology that is based on subtractive hybridization, which specifically removes all repetitive elements from the probe that are dispersed throughout the target area of interest. Eliminating these repeat sequences leads to more specific binding kinetics and makes the need for blocking DNA obsolete. This results in brighter signals and reduced background noise.


Through collaborations with leading institutions world-wide, we are continuously expanding our Kreatech FISH Probe range of more than 400 products.

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This technology is based on a proprietary subtractive hybridization specifically removing all repetitive elements which are dispersed throughout the human genome. Eliminating these repeat sequences leads to a more specific binding kinetics and makes the need to use Cot1 DNA for pre-annealing obsolete. In addition, our DNA probes are labeled with Kreatech’s proprietary ULS™ linkage system leading to a very homogenous and consistent labeling of fluorescent dyes.