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Mesothelial cell proliferations that are not unequivocally malignant are termed atypical mesothelial proliferations or atypical mesothelial hyperplasia. Frequently, pathologists are challenged with regards to classifying such mesothelial proliferations as representing a malignancy (i.e. mesothelioma) or benign reactive hyperplasia. This presentation will focus on the combined use of p16INK4a FISH and BAP1 immunohistochemistry as a diagnostic tool for the evaluation of such atypical mesothelial proliferations. A short overview of the diagnostic work-up of mesothelioma versus benign reactive mesothelial proliferations will be presented as well. Lastly, the impact on patient care for BAP1 and P16 FISH testing in this setting will be discussed.
- Review of atypical mesothelial proliferations versus mesothelioma from a pathologist point of view.
- Diagnostic use of BAP1 IHC and p16 FISH will be discussed.
- Immunohistochemical and molecular testing for diagnosis of mesothelioma will be reviewed.
- Criteria for diagnosis of mesothelioma will also be reviewed and discussed.
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