Neuroscience

• Article
  Sacrifice Perfusion in Animal Research
  

  16. Jan 2012 Authors: Miles Cunningham, Charles W. Scouten, Ph.D. Institutes: McLean Hospital of Harvard University, Belmont, MA, USA, Leica Biosystems, Wetzlar, Germany

  Neuroscience research very frequently requires animal sacrifice and microscopic examination of the brain. Certainly, stereotaxic surgery is always followed by histological examination, if only to confirm the correct placement of the probe. Read article
  
  
• Tutorial
  Freezing Biological Samples
  

  12. Jan 2012 Authors: Miles Cunningham, Charles W. Scouten, Ph.D. Institutes: McLean Hospital of Harvard University, Belmont, MA, USA, Leica Biosystems, Wetzlar, Germany

  Neuroscience researchers usually need to see slices of whole brain in order to determine the location in brain of detail they are viewing under the microscope. The brain needs to be hardened to allow cutting the thin slices, unless a vibrating blade microtome, which is much slower, is used. Read article
  
  
• Tutorial
  Stereotaxic Accuracy
  

  02. Nov 2010 Author: Charles W. Scouten, Ph.D. Institute: Leica Biosystems, Wetzlar, Germany

  Together with a suitable manipulator and oriented head holder, brain maps can be used to position probes at a preplanned site in the brains of several rodents. The instrument for moving a probe to a given coordinate in space – inside the brain – is a stereotaxic instrument. Read article
  
  
• Article
  Navigator through the Brain - Stereotaxic Atlases for Neuroscience Research
  

  07. Sep 2009 Author: Charles W. Scouten, Ph.D. Institute: Leica Biosystems, Wetzlar, Germany

  Dr. George Paxinos paved the way for future neuroscience research by being the first to produce an accurate 3D stereotaxic atlas to guide placement of electrodes and injections in the brain of experimental animals. His atlases are now international standards. Read article