Article16. Jan 2012 Institutes: McLean Hospital of Harvard University, Belmont, MA, USA, Leica Biosystems, Wetzlar, GermanyNeuroscience research very frequently requires animal sacrifice and microscopic examination of the brain. Certainly, stereotaxic surgery is always followed by histological examination, if only to confirm the correct placement of the probe.
Tutorial12. Jan 2012 Institutes: McLean Hospital of Harvard University, Belmont, MA, USA, Leica Biosystems, Wetzlar, GermanyNeuroscience researchers usually need to see slices of whole brain in order to determine the location in brain of detail they are viewing under the microscope. The brain needs to be hardened to allow cutting the thin slices, unless a vibrating blade microtome, which is much slower, is used.
Tutorial02. Nov 2010 Institute: Leica Biosystems, Wetzlar, GermanyTogether with a suitable manipulator and oriented head holder, brain maps can be used to position probes at a preplanned site in the brains of several rodents. The instrument for moving a probe to a given coordinate in space – inside the brain – is a stereotaxic instrument.
Article07. Sep 2009 Institute: Leica Biosystems, Wetzlar, GermanyDr. George Paxinos paved the way for future neuroscience research by being the first to produce an accurate 3D stereotaxic atlas to guide placement of electrodes and injections in the brain of experimental animals. His atlases are now international standards.