Tyrosinase-Related Protein-1 Primary Antibodies

Tyrosinase-Related Protein-1 Novocastra

Human malignant melanoma: immunohistochemical staining for tyrosinase-related protein-1 using NCL-TRP-1. Note cytoplasmic staining of tumor cells. Paraffin section.
Human malignant melanoma: immunohistochemical staining for tyrosinase-related protein-1 using NCL-TRP-1. Note cytoplasmic staining of tumor cells. Paraffin section.

Antigen Background

Tyrosinase-related protein-1 (TRP-1) is a member of a family of proteins which are involved in melanin biosynthesis. The catalytic function of TRP-1 has not been fully resolved but the enzyme appears to be important in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid to form a high molecular weight pigmented biopolymer. In mammals, there are two basic types of melanin, the brown-black eumelanin and the reddish-yellow phaeomelanin. The concentrations of each are variable and are not related to skin type. In skin exposed to suberythemal doses of UVB, an increase in the number of melanocytes expressing TRP-1 and TRP-2 is reported with no increase in the number of tyrosinase-expressing melanocytes. In normal, untreated skin the number of melanocytes that express either TRP-1, TRP-2 or tyrosinase are similar irrespective of skin type. TRP-1 is also reported to be expressed in more than 50 percent of choroidal melanocytes in the adult eye.


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CLONE: G3E6

Material with code "TRP-1" is discontinued , possible alternatives:

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商品番号 商品名 Configuration Use Datasheet MSDS 数量
TRP-1 1ml NCL-TRP-1 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS 1