pS2 Protein Novocastra
pS2, also known as pNR-2, was first identified by differential screening of cDNA libraries from estrogen responsive breast cancer cell lines. In normal tissue, pS2 protein is reported to be expressed in gastric mucosa, small intestinal mucosa and normal breast epithelium. pS2 is estrogen regulated in breast cancer cell lines and may have some growth factor activity. In malignant epithelial tumors, pS2 has been reported to be expressed in gastric carcinomas and gynecological cancers.The pS2 mRNA and protein are expressed predominantly in estrogen receptor positive breast cancers.