Mismatch Repair Protein (MSH6) Primary Antibodies

Mismatch Repair Protein (MSH6)

Human colonic carcinoma: immunohistochemical staining for Mismatch Repair Protein 6 (MSH6) using NCL-L-MSH6. Note intense nuclear staining of a proportion of tumor cells. Paraffin section.
Human colonic carcinoma: immunohistochemical staining for Mismatch Repair Protein 6 (MSH6) using NCL-L-MSH6. Note intense nuclear staining of a proportion of tumor cells. Paraffin section.

Antigen Background

MSH6 is a 160 kD protein which is involved in DNA mismatch repair (MMR) and recombination pathways, when heterodimerized with MSH2. Defects in mismatch repair systems can cause mutations and can cause DNA microsatellite sequences to become unstable. Immunohistochemical studies have reported that MSH6 is strongly expressed in the nucleus of cells in normal colonic epithelium, especially in crypts. Expression is also found in lymphocytes. Studies have also shown that MSH6 is expressed in gastric carcinomas and endometrial carcinomas. However, sometimes expression can be lost in some endometrial carcinomas and colonic carcinomas with microsatellite instability.

Product Specific Information

The use of PBS-based diluents may result in increased background staining.


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製品の注文はこちら

商品番号 商品名 Configuration Use Datasheet MSDS 数量
PA0597 7ml MSH6 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS 1
MSH6-L-S 0.1ml NCL-L-MSH6 Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS 1
MSH6-L 1ml NCL-L-MSH6 Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS 1
MSH6-L-CE 1ml NCL-L-MSH6 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS 1
MSH6-L-CE-S 0.1ml NCL-L-MSH6 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS 1