E-Cadherin Novocastra HD

E-Cadherin

Invasive Breast Carcinoma. Clear membrane and faint cytoplasmic staining of tumor cells. Paraffin Section.
Invasive Breast Carcinoma. Clear membrane and faint cytoplasmic staining of tumor cells. Paraffin Section.

Antigen Background

E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In prostate cancers, for example, the expression of E-cadherin is reported to be reduced or absent in comparison with its expression in normal prostate which is uniformly strong. Reduced expression or absence of E-cadherin in addition to alpha, beta and gamma-catenin in primary breast carcinomas has also been reported and these four proteins are associated with the development of metastases.


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CLONE: 36B5

Material with code "E-Cadherin" is discontinued , possible alternatives:

製品の注文はこちら

商品番号 商品名 Configuration Use Datasheet MSDS 数量
PA0387 7ml E-Cadherin BondRTU Primary Bond ready to use reagent P(HIER) Info MSDS 1
E-CAD-L 1ml NCL-L-E-Cad Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS 1
E-CAD-L-CE 1ml NCL-L-E-Cad Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS 1