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Novocastra Muscle Specific Actin

Antigens Background

 Muscle Specific Actin (MSA) is a highly conserved, ubiquitous protein found in muscle and some non-muscle cells. Actins can be divided into three subsets, alpha actins found in muscle tissue cells, beta and gamma actins found in non-muscle cells and a small subset of gamma actins also found in muscle tissue cells. In normal tissues, expression is found in striated fibers of skeletal muscle, smooth muscle in arteries, veins and pericytes of smaller arteries, muscle in bowel, myometrium of the uterus, prostatic stroma, capsule cells of liver, kidney, lymph node and spleen, the myoepithelial layers of mammary ducts and glands, eccrine sweat glands and salivary glands. Expression is not found in epithelial cells, lymphoid cells, macrophages, connective tissue and neuronal cells. In neoplastic tissues, expression can be found in soft tissue tumors with muscle differentiation e.g. leiomyomas, leiomyosarcomas and rhabdomyosarcomas of varying subtypes.Non-muscle sarcomas, carcinomas, melanomas and lymphomas do not express muscle specific actin.

Human leiomyosarcoma: immunohistochemical staining for muscle specific actin using NCL-L-MSA-594
Human leiomyosarcoma: immunohistochemical staining for muscle specific actin using NCL-L-MSA-594

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CLONE: HHF35

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Code Name Configuration Use Datasheet MSDS Qty
PA0258 7ml MuscSpecAct Bond RTU Prim Bond ready to use reagent P Info MSDS
MSA-L-U 1ml NCL-L-MSA Liquid Concentrated Monoclonal Antibody P Info MSDS
MSA-U 1ml NCL-MSA US IVD Lyophilised Concentrated Monoclonal Antibody F, P, W Info MSDS
MSA 1ml NCL-MSA Lyophilised Concentrated Monoclonal Antibody F, P, W Info MSDS

CLONE: SC28

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Code Name Configuration Use Datasheet MSDS Qty
MSA-594-L 1ml NCL-L-MSA-594 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
MSA-594-L-CE 1ml NCL-L-MSA-594 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS