The Pathology Company
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Antigen Background

The Ki67 antigen is a nuclear protein which is expressed in all active parts of the cell cycle (G1, S, G2 and mitosis) but is absent in resting cells (G0). In contrast to many other cell cycle-associated proteins, the Ki67 antigen is consistently absent in quiescent cells and is not detectable during DNA repair processes. Thus, the presence of Ki67 antigen is strictly associated with the cell cycle and confined to the nucleus, suggesting an important role in the maintenance and/or regulation of the cell division cycle.

Ki67, clone MM1, Poorly Differentiated Squamous Cell Carcinoma.
Ki67, clone MM1, Poorly Differentiated Squamous Cell Carcinoma.

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Bond ready-to-use Ki67 is recommended for the assessment of cell proliferation in normal and neoplastic tissues.