The CD34 antigen is a single chain transmembrane glycoprotein with a molecular weight of 110 kD. The CD34 protein is selectively expressed on human lymphoid and myeloid hemopoietic progenitor cells. The CD34 antigen is also expressed on vascular enothelium.
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Enzyme digestion of paraffin sections is recommended with Clone QBEnd/10 in preference to heat induced epitope retrieval as it produces stronger staining and reduces background elastin staining.