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Novocastra CD1a

Antigen Background

CD1a is a protein of 43 to 49 kD expressed on dendritic cells and cortical thymocytes. CD1a antigen expression has been shown to be useful in differentiating Langerhans cells, powerful antigen presenting cells present in skin and epithelia, from interdigitating cells. Immunohistochemical studies for CD1a antigen have reported a reduction in epidermal Langerhans cells in graft versus host disease and the participation of CD1a antigen-positive dendritic cells in atherosclerotic lesion formation and asthmatic inflammation.

Product Specific Information

Clone MTB1 detects cortical thymocytes, Langerhans cells in epidermis, interdigitating cells of dermis and interdigitating cells of stratified squamous epithelium of tonsil. Clone MTB1 may also detect small focal groups of lymphocytes outside the germinal centers of tonsil indicating a cross-reaction with CD1b antigen. Clone JPM30 detects cortical thymocytes, Langerhans cells in epidermis, interdigitating cells of dermis, interdigitating cells of stratified squamous epithelium of tonsil but in addition it stains sweat gland ducts in the dermis and epithelial cells of small intestine indicative of cross-reactivity with CD1d antigen.

Normal human skin: immunohistochemical staining for CD1a antigen using NCL-CD1a-235. Note intense membrane staining of Langerhans cells. Paraffin section.
Normal human skin: immunohistochemical staining for CD1a antigen using NCL-CD1a-235. Note intense membrane staining of Langerhans cells. Paraffin section.

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