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Novocastra Beta-Catenin

Antigen Background

The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton.Beta-catenin's role is as a transcription effector of the wnt-signalling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.

Human endometrial adenocarcinoma: immunohistochemical staining for beta-catenin using NCL-B-CAT. Note membrane staining of tumor cells. Paraffin section.
Human endometrial adenocarcinoma: immunohistochemical staining for beta-catenin using NCL-B-CAT. Note membrane staining of tumor cells. Paraffin section.

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CLONE: 17C2

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Code Name Configuration Use Datasheet MSDS Qty
PA0083 7ml Beta-Catenin Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
B-CAT-L-U 1ml NCL-L-B-CAT Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
B-CAT-U 1ml NCL-B-CAT US IVD Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W MSDS
B-CAT-S 0.1ml NCL-B-CAT Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS
B-CAT 1ml NCL-B-CAT Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS