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Zap-70 Primary Antibodies

Zap-70

Human B cell chronic lymphocytic leukemia: immunohistochemical staining for ZAP-70 antigen using NCL-L-ZAP-70. Note staining of malignant lymphocytic leukemic cells and intense staining of infiltrating T lymphocytes. Paraffin section.
Human B cell chronic lymphocytic leukemia: immunohistochemical staining for ZAP-70 antigen using NCL-L-ZAP-70. Note staining of malignant lymphocytic leukemic cells and intense staining of infiltrating T lymphocytes. Paraffin section.

Antigen Background

ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.

 

 


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CLONE: L453R

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Code Name Configuration Use Datasheet MSDS Qty
PA0998 7ml ZAP-70 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
ZAP-70-L-CE-S 0.1ml NCL-L-ZAP-70 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
ZAP-70-L-CE 1ml NCL-L-ZAP-70 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
ZAP-70-L-S 0.1ml NCL-L-ZAP-70 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
ZAP-70-L 1ml NCL-L-ZAP-70 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS