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Wilms' Tumor Primary Antibodies

Wilms' Tumor

Human Wilms tumor: immunohistochemical staining for WT1 using NCL-L-WT1-562.  Note intense nuclear staining of malignant cells. Paraffin section.
Human Wilms tumor: immunohistochemical staining for WT1 using NCL-L-WT1-562. Note intense nuclear staining of malignant cells. Paraffin section.

Antigen Background

Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear. 


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Code Name Configuration Use Datasheet MSDS Qty
PA0562 7ml Wilms Tumor Bond RTU Prim Bond ready to use reagent P(HIER) Info MSDS
WT1-562-L-S 0.1ml NCL-L-WT1-562 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
WT1-562-L-CE-S 0.1ml NCL-L-WT1-562 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
WT1-562-L-CE 1ml NCL-L-WT1-562 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS