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Utrophin Muscle Disease Antibodies

Utrophin

Human skeletal muscle: IHC staining for utrophin using NCL-DRP2 antibody.  In control muscle the antibody labels blood vessels and neuromuscular junctions (A).  Utrophin is expressed at the sarcolemma in individuals with mutations in the DMD gene (B).
Human skeletal muscle: IHC staining for utrophin using NCL-DRP2 antibody. In control muscle the antibody labels blood vessels and neuromuscular junctions (A). Utrophin is expressed at the sarcolemma in individuals with mutations in the DMD gene (B).

Antigen Background

The utrophin gene is located on chromosome 6. The protein is a homologue of dystrophin and is known as dystrophin-related protein. In normal muscle, utrophin is restricted to neuromuscular junctions; however, in dystrophin-deficient muscle, utrophin expression may be upregulated and labeling appears around the periphery of most fibers. lmmunohistochemical staining with NCL-DRP2 labels vessels and neuromuscular junctions and the upregulated form of utrophin, located around fiber membranes.


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CLONE: DRP3/20C5

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Code Name Configuration Use Datasheet MSDS Qty
DRP2-CE-S 1ml NCL-DRP2 Lyophilised Concentrated Monoclonal Antibody E, F Info MSDS
DRP2-CE 2.5ml NCL-DRP2 Lyophilised Concentrated Monoclonal Antibody F Info MSDS
DRP2 2.5ml NCL-DRP2 Lyophilised Concentrated Monoclonal Antibody E, F Info MSDS