Warning! You won't be able to use the quotation basket until you enable cookies in your Web browser.
Warning! Your Web browser is no longer supported. Please upgrade to a modern browser.
Utrophin Muscle Disease Antibodies

Utrophin

Human skeletal muscle: IHC staining for utrophin using NCL-DRP2 antibody.  In control muscle the antibody labels blood vessels and neuromuscular junctions (A).  Utrophin is expressed at the sarcolemma in individuals with mutations in the DMD gene (B).
Human skeletal muscle: IHC staining for utrophin using NCL-DRP2 antibody. In control muscle the antibody labels blood vessels and neuromuscular junctions (A). Utrophin is expressed at the sarcolemma in individuals with mutations in the DMD gene (B).

Antigen Background

The utrophin gene is located on chromosome 6. The protein is a homologue of dystrophin and is known as dystrophin-related protein. In normal muscle, utrophin is restricted to neuromuscular junctions; however, in dystrophin-deficient muscle, utrophin expression may be upregulated and labeling appears around the periphery of most fibers. lmmunohistochemical staining with NCL-DRP2 labels vessels and neuromuscular junctions and the upregulated form of utrophin, located around fiber membranes.


loading...
Some products are not available in your region, please contact your Leica Biosystems representative to find a solution that is right for you.