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Tyrosine Hydroxylase Primary Antibodies

Tyrosine Hydroxylase Novocastra

Human midbrain: immunohistochemical staining of tyrosine hydroxylase enzyme using  NCL-TH. Note cytoplasmic staining of catecholaminergic cells and their processes.  Paraffin section (Peroxidase substrate: nickel DAB, Counterstain: eosin).
Human midbrain: immunohistochemical staining of tyrosine hydroxylase enzyme using NCL-TH. Note cytoplasmic staining of catecholaminergic cells and their processes. Paraffin section (Peroxidase substrate: nickel DAB, Counterstain: eosin).

Antigen Background

Tyrosine hydroxylase is the first enzyme in catecholamine (CA) biosynthesis and catalyzes the conversion of L-tyrosine to L-DOPA. Tyrosine hydroxylase is reported to be expressed in all CA neurons. Despite the abundant data about the distribution of catecholaminergic neurons in a wide variety of species, data on their distribution in the human brain is less comprehensive. However, one such study has reported that tyrosine hydroxylase products in the substantia nigra were restricted to neural bodies, axons and dendrites. These in turn were restricted to the third decade of life and their number increased in this location with age. This finding may be related to ageing of melanin-pigmented neurons.

Product Specific Information

NCL-TH is reactive with tyrosine hydroxylase in human, mouse and rat brain tissue.


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Code Name Configuration Use Datasheet MSDS Qty
TH-L-U 1ml NCL-L-TH Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
TH-U 1ml NCL-TH US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS