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Topoisomerase II Alpha Primary Antibodies

Topoisomerase II Alpha Novocastra

Human bladder tumor: immunohistochemical staining for topoisomerase II alpha using NCL-TOPOIIA. Note intense nuclear staining of malignant cells and occasional mitotic  figures. Paraffin section.
Human bladder tumor: immunohistochemical staining for topoisomerase II alpha using NCL-TOPOIIA. Note intense nuclear staining of malignant cells and occasional mitotic figures. Paraffin section.

Antigen Background

Topoisomerase II alpha is an essential nuclear enzyme involved in DNA replication and is a target for many anti-cancer drugs used for cancer therapy. Decreased expression of topoisomerase II alpha is the predominant mechanism of resistance to several chemotherapeutic agents. A significant variation in the range of expression of this protein has been reported in many different tumors. Reports of the analysis of primary breast tumors have indicated that topoisomerase II beta is more widely expressed than topoisomerase II alpha. Topoisomerase II alpha expression and activity is linked to the cell cycle and is associated with the proliferation status of cells.


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Code Name Configuration Use Datasheet MSDS Qty
TOPOIIA-L-U 1ml NCL-L-TOPOIIA Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
TOPOIIA-U 1ml NCL-TOPOIIA US IVD Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS
TOPOIIA-S 0.1ml NCL-TOPOIIA Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS