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Thyroid Transcription Factor-1 Primary Antibodies

Thyroid Transcription Factor-1 Novocastra

Human pulmonary adenocarcinoma: immunohistochemical staining for thyroid transcription factor-1 using NCL-TTF-1. Note nuclear staining in a proportion of tumor cells. Paraffin section.
Human pulmonary adenocarcinoma: immunohistochemical staining for thyroid transcription factor-1 using NCL-TTF-1. Note nuclear staining in a proportion of tumor cells. Paraffin section.

Antigen Background

Thyroid transcription factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins.Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98 percent homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities.

 

 


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Code Name Configuration Use Datasheet MSDS Qty
PA0364 7ml TTF-1 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
TTF-1-L-CE 1ml NCL-L-TTF-1 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
TTF-1-L 1ml NCL-L-TTF-1 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
TTF-1-S 0.1ml NCL-TTF-1 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
TTF-1-CE-S 0.1ml NCL-TTF-1 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
TTF-1-CE 1ml NCL-TTF-1 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
TTF-1 1ml NCL-TTF-1 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS