Synaptic Vesicle Protein 2 Novocastra
Synaptic vesicle protein 2 (SV2) is an integral membrane glycoprotein. It is required for normal neurotransmission and may play a role in the regulation of calcium-stimulated exocytosis. SV2 exists in three isoforms, SV2A, SV2B and SV2C, each containing 12 transmembrane spanning regions. SV2 proteins are reported to be among the most abundant and conserved components of synaptic vesicles in vertebrates. They are present on all small synaptic vesicles independent of transmitter type. SV2A and SV2B are reported to be widely distributed in the nervous system, whereas SV2C is only observed in a small number of neurons in a few areas of the brain. In the brain, SV2A is reported to be expressed at the highest levels in subcortical regions, whereas the highest level of expression of SV2B is in the cortex and hippocampus. SV2 is also reported to be expressed on secretory vesicles of neuroendocrine cells in the gastrointestinal tract, pancreas, anterior pituitary gland, thyroid, parathyroid and adrenal medulla, and also in exocrine chief cells of gastric mucosa.
Product Specific Information
NCL-SV2 was raised to the N-terminal cytoplasmic region of the SV2A isoform.