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Surfactant Protein A Primary Antibodies

Surfactant Protein A Novocastra

Human lung adenocarcinoma: immunohistochemical staining for surfactant protein A using NCL-SP-A. Note intense cytoplasmic staining of type II pneumocytes and alveolar macrophages. Paraffin section.
Human lung adenocarcinoma: immunohistochemical staining for surfactant protein A using NCL-SP-A. Note intense cytoplasmic staining of type II pneumocytes and alveolar macrophages. Paraffin section.

Antigen Background

Pulmonary surfactant plays a critical role in maintaining the structural integrity of the respiratory epithelium by reducing surface tension during expiration. It is a lipoprotein complex which is synthesized and secreted into the alveoli of the lung by type II pneumocytes. Lung surfactant protein-A (SP-A) is a major phospholipid-associated glycoprotein in surfactant and is a member of the C-type lectin superfamily that also inhibits lipid secretion and enhances the uptake of phospholipid by alveolar type II cells. Levels of SP-A in amniotic fluid are reported to reflect the degree of fetal lung maturity and inadequate levels of surfactant at birth, a frequent occurrence in premature infants, results in respiratory failure.

 

 


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Code Name Configuration Use Datasheet MSDS Qty
SP-A-L-U 1ml NCL-L-SP-A Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
SP-A-S 0.1ml NCL-SP-A Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
SP-A-U 1ml NCL-SP-A US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER) MSDS