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PLK-1 Primary Antibodies

PLK-1

Squamous cell carcinoma of oro-pharyngeal: Intense nuclear and cytoplasmic staining of a proportion of proliferating malignant cells.
Squamous cell carcinoma of oro-pharyngeal: Intense nuclear and cytoplasmic staining of a proportion of proliferating malignant cells.

Antigen Background

Polo-Like Kinase-1 (PLK1, also known as Serine/Threonine Protein Kinase 13) is a 66 kDa kinase. The activity of PLK-1 is crucial for mitosis & maintenance of genome stability. PLK-1 localizes to centrosomes & kinetochores where it plays a key role in late prophase & prometaphase. PLK-1 is overexpressed in many types of cancers and mediates estrogen receptor-mediated gene transcription in breast cancer cells.

Overexpression of PLK-1 is associated with tumour development, with elevated levels of expression reported in non-small cell lung cancers, head & neck, gastric, breast, ovarian, colon and several other cancer types.


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CLONE: MJS1

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Code Name Configuration Datasheet MSDS Qty
PLK-1-L-CE 1ml NCL-L-PLK-1 Liquid Concentrated Monoclonal Antibody Info MSDS