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Plasminogen Activator Inhibitor (Type 1) Primary Antibodies

Plasminogen Activator Inhibitor (Type 1) Novocastra

Human ovarian adenocarcinoma: immunohistochemical staining for plasminogen activator inhibitor (Type 1) using NCL-PAI-1. Note intense cytoplasmic staining of malignant tumor cells. Paraffin section.
Human ovarian adenocarcinoma: immunohistochemical staining for plasminogen activator inhibitor (Type 1) using NCL-PAI-1. Note intense cytoplasmic staining of malignant tumor cells. Paraffin section.

Antigen Background

Plasminogen activator inhibitor (Type 1), PAI-1 is a 48 kD protein which inhibits the conversion of plasminogen to plasmin. It is the principal inhibitor of the plasminogen activators t-PA and u-PA. PAI-1 is structurally related to the serine protease inhibitor (serpin) superfamily. The serpins are known to undergo a conformational rearrangement upon cleavage of the reactive central peptide bond (P1-P1') and it is this conformational difference between the active and cleaved forms which determine their reactivity.PAI-1 is reported to be expressed by endothelial cells and is stored in platelets.

 

 


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CLONE: TJA6

Material with code "PAI-1" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
PAI-1 1ml NCL-PAI-1 Lyophilised Concentrated Monoclonal Antibody P Info MSDS
PAI-1-S 0.1ml NCL-PAI-1 Lyophilised Concentrated Monoclonal Antibody P Info MSDS
PAI-1-U 1ml NCL-PAI-1 US IVD Lyophilised Concentrated Monoclonal Antibody P Info MSDS