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Placental Alkaline Phosphatase Primary Antibodies

Placental Alkaline Phosphatase Novocastra

Seminoma: immunohistochemical staining with Bond ready-to-use Placental Alkaline Phosphatase (8A9) using Bond Polymer Refine Detection.
Seminoma: immunohistochemical staining with Bond ready-to-use Placental Alkaline Phosphatase (8A9) using Bond Polymer Refine Detection.

Antigen Background

Placental alkaline phosphatase (PLAP) is a membrane-associated sialoglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85 percent homology with PLAP itself. This high degree of homology between PLAP and PLAP-like enzyme together with cross-reacting antibodies has led to some confusion of the distribution of PLAP and PLAP like enzyme in various tissues. PLAP is reported to be expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. PLAP expression is rare in malignant germ cell tumors. PLAP-like enzyme is reported to be predominantly found in normal fetal and neonatal testis, and in thymus. It is also commonly expressed in germ cell tumors and more recently described in seminomas.

 Product Specific Information

Reports indicate that clone 8A9 stains seminomas and placenta indicating a specificity for both PLAP and PLAP-like enzyme.


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CLONE: 8A9

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Code Name Configuration Use Datasheet MSDS Qty
PA0161 7ml PLAP Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
PLAP-8A9-L-CE 1ml NCL-L-PLAP-8A9 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
PLAP-8A9-L 1ml NCL-L-PLAP-8A9 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
PLAP-8A9-CE-S 0.1ml NCL-PLAP-8A9 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
PLAP-8A9-S 0.1ml NCL-PLAP-8A9 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
PLAP-8A9-CE 1ml NCL-PLAP-8A9 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
PLAP-8A9 1ml NCL-PLAP-8A9 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
PLAP-8A9-R-7 7ml RTU-PLAP-8A9 Ready to Use Monoclonal Antibody P(HIER) Info MSDS