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Peripherin Primary Antibodies

Peripherin Novocastra

Human small bowel: immunohistochemical staining for peripherin using NCL-PERIPH.  Note intense cytoplasmic staining of enteric ganglion cells and neural elements.  Paraffin section.
Human small bowel: immunohistochemical staining for peripherin using NCL-PERIPH. Note intense cytoplasmic staining of enteric ganglion cells and neural elements. Paraffin section.

Antigen Background

Peripherin is a 57 kD type III intermediate filament protein that is expressed in peripheral neurons, including enteric ganglion cells. Peripherin is expressed in the developing peripheral nervous system and is highly enriched in neuronal derivatives of the neural crest. The expression or absence of peripherin may be used to demonstrate abnormalities of the enteric nervous system.The assessment of the density of ganglion cells is of importance in Hirschsprung's disease (HD) -related disorders.

 

 


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