p73 Protein (alpha) Novocastra
p73 protein was the first identified homolog of the tumor suppressor gene, p53. Overproduction of p73 protein reported in p53-defective tumor cells, activates p53-responsive promoters. This results in the induction of apoptosis but its function in tumor development is unclear. Alternative splicing produces at least six known p73 mRNA species resulting in p73 isoforms; alpha, beta, gamma, delta, epsilon and zeta. The relative expression level of each splice variant may modulate p73 transcriptional and growth suppression activity.p73 protein expression is reported to be low in normal tissues eg normal squamous epithelium. Elevated expression has been shown by RT-PCR and/or western blotting in a number of tumors.
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|P73-U||1ml NCL-p73 US IVD||Lyophilised Concentrated Monoclonal Antibody||Info||MSDS||
|P73||1ml NCL-P73||Lyophilised Concentrated Monoclonal Antibody||F, P(HIER)||Info||MSDS||