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p73 Protein (alpha) Primary Antibodies

p73 Protein (alpha) Novocastra

Normal human cervix: immunohistochemical staining for p73 protein using NCL-p73.  Note nuclear staining of basal epithelial cells.
Normal human cervix: immunohistochemical staining for p73 protein using NCL-p73. Note nuclear staining of basal epithelial cells.

Antigen Background

p73 protein was the first identified homolog of the tumor suppressor gene, p53. Overproduction of p73 protein reported in p53-defective tumor cells, activates p53-responsive promoters. This results in the induction of apoptosis but its function in tumor development is unclear. Alternative splicing produces at least six known p73 mRNA species resulting in p73 isoforms; alpha, beta, gamma, delta, epsilon and zeta. The relative expression level of each splice variant may modulate p73 transcriptional and growth suppression activity.p73 protein expression is reported to be low in normal tissues eg normal squamous epithelium. Elevated expression has been shown by RT-PCR and/or western blotting in a number of tumors.


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Code Name Configuration Use Datasheet MSDS Qty
P73-U 1ml NCL-p73 US IVD Lyophilised Concentrated Monoclonal Antibody Info MSDS
P73 1ml NCL-P73 Lyophilised Concentrated Monoclonal Antibody F, P(HIER) Info MSDS