Osteopontin is a 34 kD extracellular matrix protein with a cell binding domain. Other molecules which share this domain include fibronectin, vitronectin and a variety of other extracellular proteins that bind members of the integrin family of cell surface receptors. Osteopontin was originally identified as a major component of the non-collagenous organic bone matrix, however, it has subsequently been demonstrated in a wide range of normal adult tissues and body fluids. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Osteopontin is reported to be linked to tumorigenesis and metastasis in several experimental animal models and human cancers. In breast carcinomas, demonstrated by RT-PCR and in situ hybridization studies, expression was confined to tumor cells. It is also reported to be expressed in normal breast, including vascular endothelial cells, macrophages, myoepithelial cells, osteosarcomas but not in lymphoid tumors. Other studies using in situ hybridization have shown expression in the epithelium of gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, salivary and sweat glands. Ganglion cells in the bowel also express osteopontin, as do macrophages, T cells and NK cells upon activation. Expression of osteopontin in vascular smooth muscle and endothelium may be triggered by atherosclerosis, vascular calcification and by hypertension.
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|O-PONTIN-L-U||1ml NCL-L-O-PONTIN||Liquid Concentrated Monoclonal Antibody||P(HIER)||Info||MSDS||
|O-PONTIN-U||1ml NCL-O-PONTIN US IVD||Lyophilised Concentrated Monoclonal Antibody||P(HIER)||Info||MSDS||
|O-PONTIN-S||0.1ml NCL-O-PONTIN-S||Lyophilised Concentrated Monoclonal Antibody||P(HIER)||Info||MSDS||
|O-PONTIN||1ml NCL-O-PONTIN||Lyophilised Concentrated Monoclonal Antibody||P(HIER)||Info||MSDS||