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Multi-Cytokeratin (AE1,AE3) Primary Antibodies

Multi-Cytokeratin (AE1,AE3)

Multi Cytokeratin (AE1,AE3), Human Tonsil. Click to view under virtual microscope.
Multi Cytokeratin (AE1,AE3), Human Tonsil. Click to view under virtual microscope.

Antigen Background

Keratins are a family of water insoluble proteins of 40 to 70 kD. These proteins form tonofilaments, a class of intermediate filament, in epidermis as well as in almost all other epithelia. The process of normal epidermal differentiation is characterized by a series of morphological and biochemical changes as cells progress from the germinative basal layer through the spinous and granular layers to the outer cornified layer. The 65 to 67 kD cytokeratins are reported to be present only above the basal layer, the 58 kD cytokeratin is reported to be expressed throughout the entire epidermis including the basal layer and the 56 kD cytokeratin is reported to be absent from the basal layer and is normally eliminated during stratum corneum formation. The 56 and 65 to 67 kD cytokeratins are reported to be characteristic of epidermal cells undergoing terminal differentiation and may be considered as molecular markers for keratinization.

Product Specific Information

Clones AE1 and AE3 are specific for the 56.5, 50, 50', 48 and 40 kD acidic cytokeratins as well as the 65 to 67, 64, 59, 58, 56 and 52 kD basic cytokeratins. The cocktail of clones AE1 and AE3 exhibit broad reactivity with two families of cytokeratin, acidic and basic.


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CLONE: AE1/AE3

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Code Name Configuration Use Datasheet MSDS Qty
PA0909 7ml AE1/AE3 Bond RTU Primary Bond ready to use reagent P(ENZYME) Info MSDS
PA0012 7ml Multi-Cytokeratin Bond RTU Primary Bond ready to use reagent Info MSDS
AE1/AE3-L-CE 1ml NCL-L-AE1/AE3 Liquid Monoclonals P(HIER) Info
AE1/AE3-601-L-CE 1ml NCL-L-AE1/AE3-601 Liquid Monoclonals P(HIER) Info MSDS
AE1/AE3-CE-S 0.1ml NCL-AE1/AE3 Lyophilised Monoclonals F, P(HIER) Info MSDS
AE1/AE3-CE 1ml NCL-AE1/AE3 Lyophilised Monoclonals P(HIER) Info MSDS