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Mast Cell Tryptase Primary Antibodies

Mast Cell Tryptase Novocastra

Human appendix: immunohistochemical staining for mast cell tryptase using NCL-MCTRYP-428. Note cytoplasmic staining of mast cells. Paraffin section.
Human appendix: immunohistochemical staining for mast cell tryptase using NCL-MCTRYP-428. Note cytoplasmic staining of mast cells. Paraffin section.

Antigen Background

Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of tryptase is reported to be found in mast cells of skin and lung and suggests this enzyme plays a major role in mast cell mediated events. In vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin and activate latent collagenase. Models of allergenic disease in the skin, nose and lung have each indicated elevated tryptase levels. Human mast cell tryptase has been reported to be implicated as a mediator of inflammation. Mast cell degranulation in the gut causes mucus secretion, mucosal edema, increased gut permeability and may be responsible for some of the symptoms and signs of inflammatory bowel disease.


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CLONE: 10D11

Material with code "Mast Cell Tryptase" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
PA0019 7ml Mast Cell Tryp BondRTUPrim Bond ready to use reagent P Info MSDS
MCTRYP-428-L-U 1ml NCL-L-MCTRYP-428 Liquid Concentrated Monoclonal Antibody P Info MSDS
MCTRYP-428-U 1ml NCL-MCTRYP-428 US IVD Lyophilised Concentrated Monoclonal Antibody P Info MSDS
MCTRYP-428 1ml NCL-MCTRYP-428 Lyophilised Concentrated Monoclonal Antibody P Info MSDS
MCTRYP-428-S 0.1ml NCL-MCTRYP-428 Lyophilised Concentrated Monoclonal Antibody P Info MSDS