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Kip2 (p57 Protein) Primary Antibodies

Kip2 (p57 Protein) Novocastra

Normal human placenta: immunohistochemical staining for p57 (Kip2). Note nuclear staining in a proportion of cytotrophoblastic and intermediate trophoblastic cells. p57 (Kip2): clone 25B2.
Normal human placenta: immunohistochemical staining for p57 (Kip2). Note nuclear staining in a proportion of cytotrophoblastic and intermediate trophoblastic cells. p57 (Kip2): clone 25B2.

Antigen Background

Cyclin dependent kinases are positive regulators of cell proliferation. p57 is an inhibitor of cyclin-dependent kinases, a tumour suppressor, and is involved in apoptosis and differentiation. It is closely-related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms tumours and tumours associated with the Beckwith-Wiedemann syndrome. There is increasing interest in p57 as a marker in Gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviours.


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CLONE: 25B2

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Code Name Configuration Use Datasheet MSDS Qty
P57-L-CE 1ml NCL-L-p57 Liquid Concentrated Monoclonal Antibody P(HIER) Info
P57-L-U 1ml NCL-L-p57 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57-L-U 1ml NCL-L-p57 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57 1ml NCL-p57 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57-U 1ml NCL-p57 US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57-S 0.1ml NCL-p57 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS