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Kip2 (p57 Protein) Primary Antibodies

Kip2 (p57 Protein) Novocastra

Antigen Background

Cyclin dependent kinases are positive regulators of cell proliferation. p57 protein acts as a tumor suppressor to counter this. It is closely-related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms tumors and tumors associated with the Beckwith-Wiedemann syndrome. There is increasing interest in p57 as a marker in Gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors. Recent developments in changes in the criteria for histologic diagnosis of these lesions due to earlier clinical diagnosis have been reviewed Hui P et al., Advantages in Anatomical Pathology. 12(3): 116-125 (2005) and the ability to make more accurate diagnoses due to the introduction of newer antibodies such as p57 is discussed.

 

 


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Code Name Configuration Use Datasheet MSDS Qty
P57-L-U 1ml NCL-L-p57 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57-L-U 1ml NCL-L-p57 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57 1ml NCL-p57 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57-U 1ml NCL-p57 US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
P57-S 0.1ml NCL-p57 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS