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Melanoma Marker (HMB45) Primary Antibodies

Melanoma Marker (HMB45)

Human metastatic melanoma: immunohistochemical staining for melanoma cells using  NCL-HMB45. Note cytoplasmic staining of malignant cells. Paraffin section
Human metastatic melanoma: immunohistochemical staining for melanoma cells using NCL-HMB45. Note cytoplasmic staining of malignant cells. Paraffin section

Antigen Background

The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells.

Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation.

Product Specific Information

The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996)).


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CLONE: HMB45

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Code Name Show all details Configuration Use Datasheet MSDS Qty
PA0625 30ml HMB45 Bond RTU Primary Bond ready to use reagent P(ENZYME) Info MSDS
PA0027 7ml HMB45 Bond RTU Primary Bond ready to use reagent P(ENZYME) Info MSDS
HMB45-L-CE 1ml NCL-L-HMB45 Liquid Concentrated Monoclonal Antibody P(ENZYME) Info MSDS
HMB45-L-CE-S 0.1ml NCL-L-HMB45 Liquid Concentrated Monoclonal Antibody P(ENZYME) Info MSDS
HMB45-L 1ml NCL-L-HMB45 Liquid Concentrated Monoclonal Antibody F, P(ENZYME) Info MSDS
HMB45-L-CE 1ml NCL-L-HMB45 Liquid Concentrated Monoclonal Antibody P(ENZYME) Info MSDS
HMB45-L-S 0.1ml NCL-L-HMB45 Liquid Concentrated Monoclonal Antibody F, P(ENZYME) Info MSDS
HMB45 1ml NCL-HMB45 Lyophilised Concentrated Monoclonal Antibody F, P(ENZYME) Info MSDS
HMB45-CE 1ml NCL-HMB45 Lyophilised Concentrated Monoclonal Antibody P(ENZYME) Info MSDS