Heat Shock Protein 90 Novocastra
Heat shock proteins are highly conserved proteins in nearly all organisms and are induced by various kinds of stress, including non-physiological temperatures. Heat shock protein 90 (Hsp90) is associated with the folding of signal-transducing proteins such as steroid hormone receptors and protein kinases. Hsp90 forms several discrete subcomplexes, each containing distinct groups of co-chaperones that function in these folding pathways. Hsp90 has been reported to be expressed in epithelial cells, mononuclear cells, giant cells, nerve cells and endothelial cells of small vessels. Hsp90 expression has been reported to be correlated with sex steroid receptor status in endometrial carcinomas. In breast cancer, MHC class I expression is reported to correlate with nuclear localization of Hsp90.