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Heat Shock Protein 105 Primary Antibodies

Heat Shock Protein 105 Novocastra

Human brain, cerebellum: immunohistochemical staining for heat shock protein 105 using  NCL-HSP105. Note intense cytoplasmic and nuclear staining of Purkinje cells and neuronal processes. Paraffin section.
Human brain, cerebellum: immunohistochemical staining for heat shock protein 105 using NCL-HSP105. Note intense cytoplasmic and nuclear staining of Purkinje cells and neuronal processes. Paraffin section.

Antigen Background

Heat shock protein 105 (Hsp105) exists as two isoforms; alpha and beta which belong to the Hsp105/Hsp110 protein family. Hsp105 acts as both a chaperone to prevent thermal aggregation of proteins and as a regulator of mammalian cells. The Hsp105 isoforms are reported to be found in the cytoplasm but not in the nucleoli under non-stressed and stressed conditions. In rodents, Hsp105 isoforms are reported to be moderately expressed in the adrenal glands, spleen, liver and heart and both are markedly increased after heat shock. In the testis, Hsp105 is specifically localized in the cytoplasm of germ cells but may translocate to the nucleus after heat shock. The most abundant expression of Hsp105 occurs in the brain with nuclear and cytoplasmic expression in nearly all neurons, oligodendrocytes, microglia and astrocytes. Increased expression reported during embryogenesis suggests that Hsp105 may have an important role during mouse development.


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Code Name Configuration Use Datasheet MSDS Qty
HSP105 1ml NCL-HSP105 Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS