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Granzyme B Primary Antibodies

Granzyme B Novocastra

Hodgkin's disease: immunohistochemical staining for granzyme B using NCL-L-GRAN-B.  Note granular cytoplasmic staining in a number of Reed Sternberg cells. Paraffin section.
Hodgkin's disease: immunohistochemical staining for granzyme B using NCL-L-GRAN-B. Note granular cytoplasmic staining in a number of Reed Sternberg cells. Paraffin section.

Antigen Background

Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.


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Code Name Configuration Use Datasheet MSDS Qty
PA0291 7ml Granzyme B Bond RTU Prim Bond ready to use reagent P(HIER) Info MSDS
GRAN-B-L-CE 1ml NCL-L-GRAN-B Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
GRAN-B-L 1ml NCL-L-GRAN-B Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
GRAN-B-CE 1ml NCL-GRAN-B Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
GRAN-B-CE-S 0.1ml NCL-GRAN-B Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
GRAN-B-S 0.1ml NCL-GRAN-B Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
GRAN-B 1ml NCL-GRAN-B Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
GRAN-B-R-7 7ml RTU-GRAN-B Ready to Use Monoclonal Antibody P(HIER) Info MSDS
GRAN-B-R-7-CE 7ml RTU-GRAN-B Ready to Use Monoclonal Antibody P(HIER) Info MSDS