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Fascin Primary Antibodies

Fascin Novocastra

Hodgkins lymphoma: immunohistochemical staining with Bond ready-to-use Fascin (IM20) using Bond Polymer Refine Detection.
Hodgkins lymphoma: immunohistochemical staining with Bond ready-to-use Fascin (IM20) using Bond Polymer Refine Detection.

Antigen Background

Human fascin is a 55 to 58 kD actin-bundling protein, whose actin binding ability is regulated by phosphorylation. In normal tissues the detection of fascin is reported to be predominantly restricted to dendritic cells, and in the thymus has been observed only in medullary dendritic cells. In reactive nodes, interdigitating reticulum cells of T cell zones, cells in subcapsular areas, and cells of the reticular network express fascin. Variable expression is seen in follicular dendritic cells and endothelial cells. Lymphoid cells, myeloid cells and plasma cells do not express fascin. However, in cases of Hodgkin's disease, including nodular sclerosis, mixed cellularity lymphocyte depletion and unclassified cases, most or all Reed Sternberg cells are reported to be positive for fascin. Fascin expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.


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CLONE: IM20

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Code Name Configuration Use Datasheet MSDS Qty
PA0420 7ml Fascin Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
FASCIN-L 1ml NCL-L-FASCIN Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS
FASCIN 1ml NCL-FASCIN Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS
FASCIN-S 0.1ml NCL-FASCIN Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS